Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology

Many malignant cells produce increased amounts of lactate, which promotes the development of myeloid-derived suppressor cells (MDSCs). MDSCs, lactate, and a low pH in the tumor microenvironment inhibit the function of natural killer (NK) cells and T lymphocytes, hence allowing for disease progressio...

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Autores principales: Husain, Zaheed, Seth, Pankaj, Sukhatme, Vikas P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881600/
https://www.ncbi.nlm.nih.gov/pubmed/24404426
http://dx.doi.org/10.4161/onci.26383
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author Husain, Zaheed
Seth, Pankaj
Sukhatme, Vikas P
author_facet Husain, Zaheed
Seth, Pankaj
Sukhatme, Vikas P
author_sort Husain, Zaheed
collection PubMed
description Many malignant cells produce increased amounts of lactate, which promotes the development of myeloid-derived suppressor cells (MDSCs). MDSCs, lactate, and a low pH in the tumor microenvironment inhibit the function of natural killer (NK) cells and T lymphocytes, hence allowing for disease progression. Ketogenic diets can deplete tumor-bearing animals from MDSCs and regulatory T cells, thereby improving their immunological profile.
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spelling pubmed-38816002014-01-08 Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology Husain, Zaheed Seth, Pankaj Sukhatme, Vikas P Oncoimmunology Author's View Many malignant cells produce increased amounts of lactate, which promotes the development of myeloid-derived suppressor cells (MDSCs). MDSCs, lactate, and a low pH in the tumor microenvironment inhibit the function of natural killer (NK) cells and T lymphocytes, hence allowing for disease progression. Ketogenic diets can deplete tumor-bearing animals from MDSCs and regulatory T cells, thereby improving their immunological profile. Landes Bioscience 2013-11-01 2013-10-09 /pmc/articles/PMC3881600/ /pubmed/24404426 http://dx.doi.org/10.4161/onci.26383 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Husain, Zaheed
Seth, Pankaj
Sukhatme, Vikas P
Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology
title Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology
title_full Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology
title_fullStr Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology
title_full_unstemmed Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology
title_short Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology
title_sort tumor-derived lactate and myeloid-derived suppressor cells: linking metabolism to cancer immunology
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881600/
https://www.ncbi.nlm.nih.gov/pubmed/24404426
http://dx.doi.org/10.4161/onci.26383
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