Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology

Many malignant cells produce increased amounts of lactate, which promotes the development of myeloid-derived suppressor cells (MDSCs). MDSCs, lactate, and a low pH in the tumor microenvironment inhibit the function of natural killer (NK) cells and T lymphocytes, hence allowing for disease progressio...

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Detalles Bibliográficos
Autores principales: Husain, Zaheed, Seth, Pankaj, Sukhatme, Vikas P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881600/
https://www.ncbi.nlm.nih.gov/pubmed/24404426
http://dx.doi.org/10.4161/onci.26383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881600/
https://www.ncbi.nlm.nih.gov/pubmed/24404426
http://dx.doi.org/10.4161/onci.26383

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