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Mechanisms of protein-folding diseases at a glance

For a protein to function appropriately, it must first achieve its proper conformation and location within the crowded environment inside the cell. Multiple chaperone systems are required to fold proteins correctly. In addition, degradation pathways participate by destroying improperly folded protei...

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Detalles Bibliográficos
Autores principales: Valastyan, Julie S., Lindquist, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882043/
https://www.ncbi.nlm.nih.gov/pubmed/24396149
http://dx.doi.org/10.1242/dmm.013474