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Caenorhabditis elegans as a model system for studying non-cell-autonomous mechanisms in protein-misfolding diseases

Caenorhabditis elegans has a number of distinct advantages that are useful for understanding the basis for cellular and organismal dysfunction underlying age-associated diseases of protein misfolding. Although protein aggregation, a key feature of human neurodegenerative diseases, has been typically...

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Detalles Bibliográficos
Autores principales: Nussbaum-Krammer, Carmen I., Morimoto, Richard I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882046/
https://www.ncbi.nlm.nih.gov/pubmed/24396152
http://dx.doi.org/10.1242/dmm.013011