Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish

Truncating mutations in adenomatous polyposis coli (APC) are strongly linked to colorectal cancers. APC is a negative regulator of the Wnt pathway and constitutive Wnt activation mediated by enhanced Wnt–β-catenin target gene activation is believed to be the predominant mechanism responsible for APC...

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Detalles Bibliográficos
Autores principales: Valvezan, Alexander J., Huang, Jian, Lengner, Christopher J., Pack, Michael, Klein, Peter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882049/
https://www.ncbi.nlm.nih.gov/pubmed/24092877
http://dx.doi.org/10.1242/dmm.012625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882049/
https://www.ncbi.nlm.nih.gov/pubmed/24092877
http://dx.doi.org/10.1242/dmm.012625

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