Promoter Methylation of MLH1, PMS2, MSH2 and p16 Is a Phenomenon of Advanced-Stage HCCs

Epigenetic silencing of tumour suppressor genes has been observed in various cancers. Looking at hepatocellular carcinoma (HCC) specific protein silencing was previously demonstrated to be associated with the Hepatitis C virus (HCV). However, the proposed HCV dependent promoter methylation of DNA mi...

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Detalles Bibliográficos
Autores principales: Hinrichsen, Inga, Kemp, Matthias, Peveling-Oberhag, Jan, Passmann, Sandra, Plotz, Guido, Zeuzem, Stefan, Brieger, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882222/
https://www.ncbi.nlm.nih.gov/pubmed/24400091
http://dx.doi.org/10.1371/journal.pone.0084453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882222/
https://www.ncbi.nlm.nih.gov/pubmed/24400091
http://dx.doi.org/10.1371/journal.pone.0084453

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