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Phosphoproteomic Analysis of Platelets Activated by Pro-Thrombotic Oxidized Phospholipids and Thrombin

Specific oxidized phospholipids (oxPC(CD36)) promote platelet hyper-reactivity and thrombosis in hyperlipidemia via the scavenger receptor CD36, however the signaling pathway(s) induced in platelets by oxPC(CD36) are not well defined. We have employed mass spectrometry-based tyrosine, serine, and th...

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Detalles Bibliográficos
Autores principales: Zimman, Alejandro, Titz, Bjoern, Komisopoulou, Evangelia, Biswas, Sudipta, Graeber, Thomas G., Podrez, Eugene A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882224/
https://www.ncbi.nlm.nih.gov/pubmed/24400094
http://dx.doi.org/10.1371/journal.pone.0084488