A Chimeric HS4-SAR Insulator (IS2) That Prevents Silencing and Enhances Expression of Lentiviral Vectors in Pluripotent Stem Cells

Chromatin insulators, such as the chicken β-globin locus control region hypersensitive site 4 (HS4), and scaffold/matrix attachment regions (SARs/MARs) have been incorporated separately or in combination into retroviral vectors (RVs) in order to increase transgene expression levels, avoid silencing...

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Detalles Bibliográficos
Autores principales: Benabdellah, Karim, Gutierrez-Guerrero, Alejandra, Cobo, Marién, Muñoz, Pilar, Martín, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882226/
https://www.ncbi.nlm.nih.gov/pubmed/24400083
http://dx.doi.org/10.1371/journal.pone.0084268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882226/
https://www.ncbi.nlm.nih.gov/pubmed/24400083
http://dx.doi.org/10.1371/journal.pone.0084268

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