Anti-Prion Activity of a Panel of Aromatic Chemical Compounds: In Vitro and In Silico Approaches

The prion protein (PrP) is implicated in the Transmissible Spongiform Encephalopathies (TSEs), which comprise a group of fatal neurodegenerative diseases affecting humans and other mammals. Conversion of cellular PrP (PrP(C)) into the scrapie form (PrP(Sc)) is the hallmark of TSEs. Once formed, PrP(...

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Detalles Bibliográficos
Autores principales: Ferreira, Natalia C., Marques, Icaro A., Conceição, Wesley A., Macedo, Bruno, Machado, Clarice S., Mascarello, Alessandra, Chiaradia-Delatorre, Louise Domeneghini, Yunes, Rosendo Augusto, Nunes, Ricardo José, Hughson, Andrew G., Raymond, Lynne D., Pascutti, Pedro G., Caughey, Byron, Cordeiro, Yraima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882252/
https://www.ncbi.nlm.nih.gov/pubmed/24400098
http://dx.doi.org/10.1371/journal.pone.0084531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882252/
https://www.ncbi.nlm.nih.gov/pubmed/24400098
http://dx.doi.org/10.1371/journal.pone.0084531

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