Anti-Prion Activity of a Panel of Aromatic Chemical Compounds: In Vitro and In Silico Approaches

The prion protein (PrP) is implicated in the Transmissible Spongiform Encephalopathies (TSEs), which comprise a group of fatal neurodegenerative diseases affecting humans and other mammals. Conversion of cellular PrP (PrP(C)) into the scrapie form (PrP(Sc)) is the hallmark of TSEs. Once formed, PrP(...

Descripción completa

Detalles Bibliográficos
Autores principales: Ferreira, Natalia C., Marques, Icaro A., Conceição, Wesley A., Macedo, Bruno, Machado, Clarice S., Mascarello, Alessandra, Chiaradia-Delatorre, Louise Domeneghini, Yunes, Rosendo Augusto, Nunes, Ricardo José, Hughson, Andrew G., Raymond, Lynne D., Pascutti, Pedro G., Caughey, Byron, Cordeiro, Yraima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882252/
https://www.ncbi.nlm.nih.gov/pubmed/24400098
http://dx.doi.org/10.1371/journal.pone.0084531

Ejemplares similares

Ejemplares similares