The thyroid hormone receptor β induces DNA damage and premature senescence

There is increasing evidence that the thyroid hormone (TH) receptors (THRs) can play a role in aging, cancer and degenerative diseases. In this paper, we demonstrate that binding of TH T3 (triiodothyronine) to THRB induces senescence and deoxyribonucleic acid (DNA) damage in cultured cells and in ti...

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Detalles Bibliográficos
Autores principales: Zambrano, Alberto, García-Carpizo, Verónica, Gallardo, María Esther, Villamuera, Raquel, Gómez-Ferrería, Maria Ana, Pascual, Angel, Buisine, Nicolas, Sachs, Laurent M., Garesse, Rafael, Aranda, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882795/
https://www.ncbi.nlm.nih.gov/pubmed/24395638
http://dx.doi.org/10.1083/jcb.201305084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882795/
https://www.ncbi.nlm.nih.gov/pubmed/24395638
http://dx.doi.org/10.1083/jcb.201305084

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