Asymmetric Synthesis of β-Substituted α-Methylenebutyro- lactones via TRIP-Catalyzed Allylation: Mechanistic Studies and Application to the Synthesis of (S)-(−)-Hydroxymatairesinol

Asymmetric allylation of (hetero)aromatic aldehydes by a zinc(II)-allylbutyrolactone species catalyzed by a chiral BINOL-type phosphoric acid gave β-substituted α-methylenebutyrolactones in 68 to >99% ee and 52–91% isolated yield. DFT studies on the intermediate Zn(2+)-complex – crucial for chira...

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Detalles Bibliográficos
Autores principales: Fuchs, Michael, Schober, Markus, Orthaber, Andreas, Faber, Kurt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2013
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883096/
https://www.ncbi.nlm.nih.gov/pubmed/24415960
http://dx.doi.org/10.1002/adsc.201300392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883096/
https://www.ncbi.nlm.nih.gov/pubmed/24415960
http://dx.doi.org/10.1002/adsc.201300392

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