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Functional Consequences of the Macrophage Stimulating Protein 689C Inflammatory Bowel Disease Risk Allele

BACKGROUND: Macrophage stimulating protein (MSP) is a serum growth factor that binds to and activates the receptor tyrosine kinase, Recepteur d'Origine Nantais (RON). A non-synonymous coding variant in MSP (689C) has been associated with genetic susceptibility to both Crohn's disease and u...

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Detalles Bibliográficos
Autores principales: Kauder, Steven E., Santell, Lydia, Mai, Elaine, Wright, Lilyan Y., Luis, Elizabeth, N'Diaye, Elsa N., Lutman, Jeff, Ratti, Navneet, Sa, Susan M., Maun, Henry R., Stefanich, Eric, Gonzalez, Lino C., Graham, Robert R., Diehl, Lauri, Faubion, William A., Keir, Mary E., Young, Judy, Chaudhuri, Amitabha, Lazarus, Robert A., Egen, Jackson G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884107/
https://www.ncbi.nlm.nih.gov/pubmed/24409221
http://dx.doi.org/10.1371/journal.pone.0083958