Cargando…

Sputum PGP is reduced by azithromycin treatment in patients with COPD and correlates with exacerbations

RATIONALE: Proline–glycine–proline (PGP), a neutrophil chemoattractant derived from the enzymatic breakdown of collagen, is elevated in sputum of patients with chronic obstructive pulmonary disease (COPD) and may contribute to disease progression. Whether sputum levels of PGP respond to therapy for...

Descripción completa

Detalles Bibliográficos
Autores principales:	O'Reilly, Philip J, Jackson, Patricia L, Wells, J Michael, Dransfield, Mark T, Scanlon, Paul D, Blalock, J Edwin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2013
Materias:	Respiratory Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884851/ https://www.ncbi.nlm.nih.gov/pubmed/24366582 http://dx.doi.org/10.1136/bmjopen-2013-004140

Ejemplares similares

N-α-PGP and PGP, potential biomarkers and therapeutic targets for COPD
por: O'Reilly, Philip, et al.
Publicado: (2009)

β-Blockers for the prevention of acute exacerbations of chronic obstructive pulmonary disease (βLOCK COPD): a randomised controlled study protocol
por: Bhatt, Surya P, et al.
Publicado: (2016)

A novel flow cytometric-based method to measure kinase inhibition in sputum from COPD subjects
por: Nicholson, G C, et al.
Publicado: (2016)

Relationship between heart failure and the risk of acute exacerbation of COPD
por: Axson, Eleanor L, et al.
Publicado: (2021)

The impact of exacerbation frequency on mortality following acute exacerbations of COPD: a registry-based cohort study
por: Schmidt, Sigrun Alba Johannesdottir, et al.
Publicado: (2014)

A prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in COPD
por: Wilkinson, Tom M A, et al.
Publicado: (2017)

Acute Exacerbation and Respiratory InfectionS in COPD (AERIS): protocol for a prospective, observational cohort study
por: Bourne, Simon, et al.
Publicado: (2014)

Phase II study of tight glycaemic control in COPD patients with exacerbations admitted to the acute medical unit
por: Archer, John R H, et al.
Publicado: (2011)

Optimising treatment for COPD – new strategies for combination therapy
por: Welte, T
Publicado: (2009)

Linking e-health records, patient-reported symptoms and environmental exposure data to characterise and model COPD exacerbations: protocol for the COPE study
por: Moore, Elizabeth, et al.
Publicado: (2016)

Rationale for azithromycin in COVID-19: an overview of existing evidence
por: Gyselinck, Iwein, et al.
Publicado: (2021)

Risk factors for acute exacerbations of COPD in a primary care population: a retrospective observational cohort study
por: Müllerová, Hana, et al.
Publicado: (2014)

Potential clinical and economic impact of optimised maintenance therapy on discharged patients with COPD after hospitalisation for an exacerbation in China
por: Salem, Ahmed, et al.
Publicado: (2021)

Eosinopenia as a biomarker for antibiotic use in COPD exacerbations: protocol for a retrospective hospital-based cohort study
por: Yang, Mei, et al.
Publicado: (2022)

PROMETHEUS: Long-Term Exacerbation and Mortality Benefits of Implementing Single-Inhaler Triple Therapy in the US COPD Population
por: Criner, Gerard, et al.
Publicado: (2023)

EXAcerbations of COPD and their OutcomeS on CardioVascular diseases (EXACOS-CV) Programme: protocol of multicountry observational cohort studies
por: Nordon, Clementine, et al.
Publicado: (2023)

Patient characteristics associated with risk of first hospital admission and readmission for acute exacerbation of chronic obstructive pulmonary disease (COPD) following primary care COPD diagnosis: a cohort study using linked electronic patient records
por: Hunter, L C, et al.
Publicado: (2016)

Sputum-Rheology-Based Strategy for Guiding Azithromycin Prescription in COPD Patients with Frequent Exacerbations: A Randomized, Controlled Study (“COPD CARhE”)
por: Charriot, Jeremy, et al.
Publicado: (2023)

Characteristics of the sputum microbiome in COPD exacerbations and correlations between clinical indices
por: Su, Linfan, et al.
Publicado: (2022)

Use of azithromycin in the treatment of acute exacerbations of COPD
por: Milstone, Aaron P
Publicado: (2008)

Community determinants of COPD exacerbations in elderly patients in Lodz province, Poland: a retrospective observational Big Data cohort study
por: Kowalczyk, Anna, et al.
Publicado: (2022)

Mortality and readmission risk for hospitalised patients with acute exacerbation of COPD with and without spirometric obstruction: a longitudinal observational study in China
por: Ren, Xiaoxia, et al.
Publicado: (2023)

Study protocol: azithromycin therapy for chronic lung disease of prematurity (AZTEC) - a randomised, placebo-controlled trial of azithromycin for the prevention of chronic lung disease of prematurity in preterm infants
por: Lowe, John, et al.
Publicado: (2020)

The matrikine N-α-PGP couples extracellular matrix fragmentation to endothelial permeability
por: Hahn, Cornelia S., et al.
Publicado: (2015)

Inhaler technique education in elderly patients with asthma or COPD: impact on disease exacerbations—a protocol for a single-blinded randomised controlled trial
por: Maricoto, Tiago, et al.
Publicado: (2019)

Prioritising outcomes for evaluating eosinophil-guided corticosteroid therapy among patients with acute COPD exacerbations requiring hospitalisation: a Delphi consensus study
por: Suehs, Carey Meredith, et al.
Publicado: (2020)

Prevalence and clinical implications of respiratory viruses in stable chronic obstructive pulmonary disease (COPD) and exacerbations: a systematic review and meta-analysis protocol
por: Kefala, Anastasia M, et al.
Publicado: (2020)

Correlation between fractional exhaled nitric oxide and sputum eosinophilia in exacerbations of COPD
por: Gao, Jie, et al.
Publicado: (2017)

Loss of GD1-positive Lactobacillus correlates with inflammation in human lungs with COPD
por: Sze, Marc A, et al.
Publicado: (2015)

Azithromycin and risk of COPD exacerbations in patients with and without Helicobacter pylori
por: Ra, Seung Won, et al.
Publicado: (2017)

Impact of COPD case finding on clinical care: a prospective analysis of the TargetCOPD trial
por: Haroon, Shamil, et al.
Publicado: (2020)

Sputum eosinophilia is a determinant of FEV1 decline in occupational asthma: results of an observational study
por: Talini, Donatella, et al.
Publicado: (2015)

Azithromycin as an add-on treatment for persistent uncontrolled asthma in adults: protocol of a systematic review and meta-analysis
por: Liu, Wei, et al.
Publicado: (2020)

Coronary heart disease and heart failure in asthma, COPD and asthma-COPD overlap
por: Ingebrigtsen, Truls Sylvan, et al.
Publicado: (2020)

1297. Azithromycin vs Beta Lactams in Acute Exacerbations of COPD
por: Kale-Pradhan, Pramodini, et al.
Publicado: (2021)

The effect of azithromycin on sputum inflammatory markers in bronchiectasis
por: Terpstra, L. C., et al.
Publicado: (2023)

The sputum transcriptome better predicts COPD exacerbations after the withdrawal of inhaled corticosteroids than sputum eosinophils
por: Ditz, Benedikt, et al.
Publicado: (2021)

Sputum Bacterial and Fungal Dynamics during Exacerbations of Severe COPD
por: Su, Jin, et al.
Publicado: (2015)

Bacterial flora in the sputum and comorbidity in patients with acute exacerbations of COPD
por: Boixeda, Ramon, et al.
Publicado: (2015)

Validation of the breathlessness, cough and sputum scale to predict COPD exacerbation
por: DeVries, Rebecca, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_m4vhe31rf1cngtagtm526h5aql