Structural Determinants of the 5′-Methylthioinosine Specificity of Plasmodium Purine Nucleoside Phosphorylase

Plasmodium parasites rely upon purine salvage for survival. Plasmodium purine nucleoside phosphorylase is part of the streamlined Plasmodium purine salvage pathway that leads to the phosphorylysis of both purines and 5′-methylthiopurines, byproducts of polyamine synthesis. We have explored structura...

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Detalles Bibliográficos
Autores principales: Donaldson, Teraya M., Ting, Li-Min, Zhan, Chenyang, Shi, Wuxian, Zheng, Renjian, Almo, Steven C., Kim, Kami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885546/
https://www.ncbi.nlm.nih.gov/pubmed/24416224
http://dx.doi.org/10.1371/journal.pone.0084384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885546/
https://www.ncbi.nlm.nih.gov/pubmed/24416224
http://dx.doi.org/10.1371/journal.pone.0084384

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