Characterization and Molecular Profiling of PSEN1 Familial Alzheimer's Disease iPSC-Derived Neural Progenitors

Presenilin 1 (PSEN1) encodes the catalytic subunit of γ-secretase, and PSEN1 mutations are the most common cause of early onset familial Alzheimer's disease (FAD). In order to elucidate pathways downstream of PSEN1, we characterized neural progenitor cells (NPCs) derived from FAD mutant PSEN1 s...

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Detalles Bibliográficos
Autores principales: Sproul, Andrew A., Jacob, Samson, Pre, Deborah, Kim, Soong Ho, Nestor, Michael W., Navarro-Sobrino, Miriam, Santa-Maria, Ismael, Zimmer, Matthew, Aubry, Soline, Steele, John W., Kahler, David J., Dranovsky, Alex, Arancio, Ottavio, Crary, John F., Gandy, Sam, Noggle, Scott A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885572/
https://www.ncbi.nlm.nih.gov/pubmed/24416243
http://dx.doi.org/10.1371/journal.pone.0084547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885572/
https://www.ncbi.nlm.nih.gov/pubmed/24416243
http://dx.doi.org/10.1371/journal.pone.0084547

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