ULK1 induces autophagy by phosphorylating Beclin-1 and activating Vps34 lipid kinase

Autophagy is the primary cellular catabolic program activated in response to nutrient starvation. Initiation of autophagy, particularly by amino acid withdrawal, requires the ULK kinases. Despite its pivotal role in autophagy initiation, little is known about the mechanisms by which ULK promotes aut...

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Detalles Bibliográficos
Autores principales: Russell, Ryan C., Tian, Ye, Yuan, Haixin, Park, Hyun Woo, Chang, Yu-Yun, Kim, Joungmok, Kim, Haerin, Neufeld, Thomas P., Dillin, Andrew, Guan, Kun-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885611/
https://www.ncbi.nlm.nih.gov/pubmed/23685627
http://dx.doi.org/10.1038/ncb2757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885611/
https://www.ncbi.nlm.nih.gov/pubmed/23685627
http://dx.doi.org/10.1038/ncb2757

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