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ULK1 induces autophagy by phosphorylating Beclin-1 and activating Vps34 lipid kinase
Autophagy is the primary cellular catabolic program activated in response to nutrient starvation. Initiation of autophagy, particularly by amino acid withdrawal, requires the ULK kinases. Despite its pivotal role in autophagy initiation, little is known about the mechanisms by which ULK promotes aut...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885611/ https://www.ncbi.nlm.nih.gov/pubmed/23685627 http://dx.doi.org/10.1038/ncb2757 |