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Age-Dependent Relevance of Endogenous 5-Lipoxygenase Derivatives in Anxiety-Like Behavior in Mice

When 5-lipoxygenase (5-LO) is inhibited, roughly half of the CNS effect of the prototypic endocannabinoid anandamide (AEA) is lost. Therefore, we decided to investigate whether inhibiting this enzyme would influence physiological functions classically described as being under control of the endocann...

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Detalles Bibliográficos
Autores principales: Leo, Luciana M., Almeida-Corrêa, Suellen, Canetti, Claudio A., Amaral, Olavo B., Bozza, Fernando A., Pamplona, Fabricio A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885659/
https://www.ncbi.nlm.nih.gov/pubmed/24416334
http://dx.doi.org/10.1371/journal.pone.0085009