Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin α()

CTNNBL1 is a spliceosome-associated protein that binds nuclear localization signals (NLSs) in splice factors CDC5L and Prp31 as well as the antibody diversifying enzyme AID. Here, crystal structures of human CTNNBL1 reveal a distinct structure from its closest homologue karyopherin-α. CTNNBL1 compri...

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Detalles Bibliográficos
Autores principales: Ganesh, Karuna, van Maldegem, Febe, Telerman, Stephanie B., Simpson, Paul, Johnson, Christopher M., Williams, Roger L., Neuberger, Michael S., Rada, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Ltd 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885797/
https://www.ncbi.nlm.nih.gov/pubmed/24269683
http://dx.doi.org/10.1016/j.febslet.2013.11.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885797/
https://www.ncbi.nlm.nih.gov/pubmed/24269683
http://dx.doi.org/10.1016/j.febslet.2013.11.013

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