Cargando…

GILT: Shaping the MHC Class II-Restricted Peptidome and CD4(+) T Cell-Mediated Immunity

The MHC class II-restricted antigen processing pathway generates peptide:MHC complexes in the endocytic pathway for the activation of CD4(+) T cells. Gamma-interferon-inducible lysosomal thiol reductase (GILT) reduces protein disulfide bonds in the endocytic compartment, thereby exposing buried epit...

Descripción completa

Detalles Bibliográficos
Autor principal:	Hastings, Karen Taraszka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2013
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885806/ https://www.ncbi.nlm.nih.gov/pubmed/24409178 http://dx.doi.org/10.3389/fimmu.2013.00429

Ejemplares similares

Exposing the Specific Roles of the Invariant Chain Isoforms in Shaping the MHC Class II Peptidome
por: Fortin, Jean-Simon, et al.
Publicado: (2013)

GILT modulates CD4(+) T cell tolerance to the melanocyte differentiation antigen tyrosinase-related protein 1
por: Rausch, Matthew P., et al.
Publicado: (2011)

How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins
por: López de Castro, José A.
Publicado: (2018)

Low GILT Expression is Associated with Poor Patient Survival in Diffuse Large B-Cell Lymphoma
por: Phipps-Yonas, Hannah, et al.
Publicado: (2013)

MHC Class II-Restricted Epitopes Containing an Oxidoreductase Activity Prompt CD4(+) T Cells with Apoptosis-Inducing Properties
por: Malek Abrahimians, Elin, et al.
Publicado: (2015)

Toward a Network Model of MHC Class II-Restricted Antigen Processing
por: Miller, Michael A., et al.
Publicado: (2013)

Peptidomes and Structures Illustrate Two Distinguishing Mechanisms of Alternating the Peptide Plasticity Caused by Swine MHC Class I Micropolymorphism
por: Wei, Xiaohui, et al.
Publicado: (2021)

Visualizing Antigen Specific CD4+ T Cells using MHC Class II Tetramers
por: James, Eddie A., et al.
Publicado: (2009)

Organizing MHC Class II Presentation
por: Fooksman, David R.
Publicado: (2014)

MHC Class II-Restricted Presentation of the Major House Dust Mite Allergen Der p 1 Is GILT-Dependent: Implications for Allergic Asthma
por: West, Laura Ciaccia, et al.
Publicado: (2013)

Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation
por: Wieczorek, Marek, et al.
Publicado: (2017)

MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis
por: Harrington, Em P, et al.
Publicado: (2023)

GILT Expression in Human Melanoma Cells Enhances Generation of Antigenic Peptides for HLA Class II-Mediated Immune Recognition
por: Hathaway-Schrader, Jessica D., et al.
Publicado: (2022)

Analyses of the TCR repertoire of MHC class II-restricted innate CD4(+) T cells
por: Kang, Byung Hyun, et al.
Publicado: (2015)

MHC Class II Polymorphisms, Autoreactive T-Cells, and Autoimmunity
por: Tsai, Sue, et al.
Publicado: (2013)

MHC Class II Auto-Antigen Presentation is Unconventional
por: Sadegh-Nasseri, Scheherazade, et al.
Publicado: (2015)

Identification of Potential MHC Class-II-Restricted Epitopes Derived from Leishmania donovani Antigens by Reverse Vaccinology and Evaluation of Their CD4+ T-Cell Responsiveness against Visceral Leishmaniasis
por: Dikhit, Manas Ranjan, et al.
Publicado: (2017)

Thymus dictates major histocompatibility complex (MHC) specificity and immune response gene phenotype of class II MHC-restricted T cells but not of class I MHC-restricted T cells
Publicado: (1984)

Cancer Neoepitopes for Immunotherapy: Discordance Between Tumor-Infiltrating T Cell Reactivity and Tumor MHC Peptidome Display
por: Wickström, Stina L., et al.
Publicado: (2019)

Re-Directing CD4(+) T Cell Responses with the Flanking Residues of MHC Class II-Bound Peptides: The Core is Not Enough
por: Holland, Christopher J., et al.
Publicado: (2013)

An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II–restricted T cells in the absence of CD4
por: Kao, Henry, et al.
Publicado: (2005)

Antigen Processing for MHC Class II Presentation via Autophagy
por: Münz, Christian
Publicado: (2012)

Regulation of MHC Class II-Peptide Complex Expression by Ubiquitination
por: Cho, Kyung-Jin, et al.
Publicado: (2013)

Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome
por: Santambrogio, Laura
Publicado: (2022)

How Do CD4(+) T Cells Detect and Eliminate Tumor Cells That Either Lack or Express MHC Class II Molecules?
por: Haabeth, Ole Audun Werner, et al.
Publicado: (2014)

The CD8 Population in CD4-deficient Mice Is Heavily Contaminated with MHC Class II–restricted T Cells
por: Tyznik, Aaron J., et al.
Publicado: (2004)

Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation
por: Baptista, Antonio P, et al.
Publicado: (2014)

HLA-DO and Its Role in MHC Class II Antigen Presentation
por: Poluektov, Yuri O., et al.
Publicado: (2013)

A Missing Switch in Peptide Exchange for MHC Class II Molecules
por: Freund, Christian, et al.
Publicado: (2019)

The natural immune response to inhaled soluble protein antigens involves major histocompatibility complex (MHC) class I-restricted CD8+ T cell-mediated but MHC class II-restricted CD4+ T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production
Publicado: (1993)

An MHC class Ib–restricted CD8 T cell response confers antiviral immunity
por: Swanson, Phillip A., et al.
Publicado: (2008)

Atheroprotective Vaccination with MHC-II Restricted Peptides from ApoB-100
por: Tse, Kevin, et al.
Publicado: (2013)

Inhibition of HLA-DM Mediated MHC Class II Peptide Loading by HLA-DO Promotes Self Tolerance
por: Denzin, Lisa K.
Publicado: (2013)

Binding of Staphylococcal Enterotoxin B (SEB) to B7 Receptors Triggers TCR- and CD28-Mediated Inflammatory Signals in the Absence of MHC Class II Molecules
por: Kunkl, Martina, et al.
Publicado: (2021)

Experimental Validation of Multi-Epitope Peptides Including Promising MHC Class I- and II-Restricted Epitopes of Four Known Leishmania infantum Proteins
por: Agallou, Maria, et al.
Publicado: (2014)

Characterization of the Class I MHC Peptidome Resulting From DNCB Exposure of HaCaT Cells
por: Bailey, Alistair, et al.
Publicado: (2020)

Thermodynamics of Peptide-MHC Class II Interactions: Not all Complexes are Created Equal
por: Ferrante, Andrea
Publicado: (2013)

High GILT Expression Is Associated with Improved Survival in Metastatic Melanoma Patients Treated with Immune Checkpoint Inhibition
por: Adams, Anngela C., et al.
Publicado: (2022)

Structural Comparison Between MHC Classes I and II; in Evolution, a Class-II-Like Molecule Probably Came First
por: Wu, Yanan, et al.
Publicado: (2021)

Ligation of MHC Class II Induces PKC-Dependent Clathrin-Mediated Endocytosis of MHC Class II
por: Masaki, Kento, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_tc2dh63gq41mg6eaq13otfuhdv