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Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium

BACKGROUND: The primary cilium coordinates signalling in development, health and disease. Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β). We have also shown the primary cilium elongates in response to...

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Detalles Bibliográficos
Autores principales: Wann, Angus KT, Thompson, Clare L, Chapple, J Paul, Knight, Martin M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886195/
https://www.ncbi.nlm.nih.gov/pubmed/24330727
http://dx.doi.org/10.1186/2046-2530-2-17