Internalized PCSK9 dissociates from recycling LDL receptors in PCSK9-resistant SV-589 fibroblasts

Secreted PCSK9 binds to cell surface LDL receptor (LDLR) and directs the receptor for lysosomal degradation. PCSK9 is potent at inducing LDLR degradation in cultured liver-derived cells, but it is considerably less active in immortalized fibroblasts. We examined PCSK9 trafficking in SV-589 human ski...

Descripción completa

Detalles Bibliográficos
Autores principales: Nguyen, My-Anh, Kosenko, Tanja, Lagace, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886665/
https://www.ncbi.nlm.nih.gov/pubmed/24296664
http://dx.doi.org/10.1194/jlr.M044156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886665/
https://www.ncbi.nlm.nih.gov/pubmed/24296664
http://dx.doi.org/10.1194/jlr.M044156

Ejemplares similares