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Intake of Dietary Phylloquinone and Menaquinones and Risk of Stroke

BACKGROUND: Dietary vitamin K intake is thought to decrease the risk of cardiovascular disease (CVD) by reducing vascular calcification, although vitamin K is also involved in coagulation. Studies investigating the association between phylloquinone intake and risk of stroke are scarce, and the relat...

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Autores principales: Vissers, Linda E. T., Dalmeijer, Geertje W., Boer, Jolanda M. A., Monique Verschuren, W. M., van der Schouw, Yvonne T., Beulens, Joline W. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886750/
https://www.ncbi.nlm.nih.gov/pubmed/24326161
http://dx.doi.org/10.1161/JAHA.113.000455
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author Vissers, Linda E. T.
Dalmeijer, Geertje W.
Boer, Jolanda M. A.
Monique Verschuren, W. M.
van der Schouw, Yvonne T.
Beulens, Joline W. J.
author_facet Vissers, Linda E. T.
Dalmeijer, Geertje W.
Boer, Jolanda M. A.
Monique Verschuren, W. M.
van der Schouw, Yvonne T.
Beulens, Joline W. J.
author_sort Vissers, Linda E. T.
collection PubMed
description BACKGROUND: Dietary vitamin K intake is thought to decrease the risk of cardiovascular disease (CVD) by reducing vascular calcification, although vitamin K is also involved in coagulation. Studies investigating the association between phylloquinone intake and risk of stroke are scarce, and the relation with menaquinones has not been investigated to date. METHODS AND RESULTS: We investigated the association between intake of phylloquinone and menaquinones and stroke in a prospective cohort of 35 476 healthy subjects. Information on occurrence of stroke was obtained by linkage to national registries, and stroke was further specified into ischemic and hemorrhagic stroke. Vitamin K intake was estimated using a validated food‐frequency questionnaire. Multivariate Cox proportional hazards models adjusted for cardiovascular risk factors, lifestyle, and other dietary factors were used to estimate the associations. During a follow‐up of 12.1±2.1 years, 580 incident cases of stroke were identified, 163 of which were hemorrhagic and 324 were ischemic. Phylloquinone intake was not associated with risk of stroke with a hazard ratio (HR) of 1.09 (95% CI: 0.85 to 1.40, P(trend) 0.41) for the highest versus lowest quartile. For intake of menaquinones similar results were found, with an HR(Q4 versus Q1) of 0.99 (95% CI: 0.75 to 1.29, P(trend) 0.82). When specifying hemorrhagic and ischemic stroke or menaquinone subtypes, no significant associations were detected. CONCLUSION: In our study, neither dietary phylloquinone nor dietary menaquinones intake were associated with stroke risk.
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spelling pubmed-38867502014-01-10 Intake of Dietary Phylloquinone and Menaquinones and Risk of Stroke Vissers, Linda E. T. Dalmeijer, Geertje W. Boer, Jolanda M. A. Monique Verschuren, W. M. van der Schouw, Yvonne T. Beulens, Joline W. J. J Am Heart Assoc Original Research BACKGROUND: Dietary vitamin K intake is thought to decrease the risk of cardiovascular disease (CVD) by reducing vascular calcification, although vitamin K is also involved in coagulation. Studies investigating the association between phylloquinone intake and risk of stroke are scarce, and the relation with menaquinones has not been investigated to date. METHODS AND RESULTS: We investigated the association between intake of phylloquinone and menaquinones and stroke in a prospective cohort of 35 476 healthy subjects. Information on occurrence of stroke was obtained by linkage to national registries, and stroke was further specified into ischemic and hemorrhagic stroke. Vitamin K intake was estimated using a validated food‐frequency questionnaire. Multivariate Cox proportional hazards models adjusted for cardiovascular risk factors, lifestyle, and other dietary factors were used to estimate the associations. During a follow‐up of 12.1±2.1 years, 580 incident cases of stroke were identified, 163 of which were hemorrhagic and 324 were ischemic. Phylloquinone intake was not associated with risk of stroke with a hazard ratio (HR) of 1.09 (95% CI: 0.85 to 1.40, P(trend) 0.41) for the highest versus lowest quartile. For intake of menaquinones similar results were found, with an HR(Q4 versus Q1) of 0.99 (95% CI: 0.75 to 1.29, P(trend) 0.82). When specifying hemorrhagic and ischemic stroke or menaquinone subtypes, no significant associations were detected. CONCLUSION: In our study, neither dietary phylloquinone nor dietary menaquinones intake were associated with stroke risk. Blackwell Publishing Ltd 2013-12-19 /pmc/articles/PMC3886750/ /pubmed/24326161 http://dx.doi.org/10.1161/JAHA.113.000455 Text en © 2013 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Research
Vissers, Linda E. T.
Dalmeijer, Geertje W.
Boer, Jolanda M. A.
Monique Verschuren, W. M.
van der Schouw, Yvonne T.
Beulens, Joline W. J.
Intake of Dietary Phylloquinone and Menaquinones and Risk of Stroke
title Intake of Dietary Phylloquinone and Menaquinones and Risk of Stroke
title_full Intake of Dietary Phylloquinone and Menaquinones and Risk of Stroke
title_fullStr Intake of Dietary Phylloquinone and Menaquinones and Risk of Stroke
title_full_unstemmed Intake of Dietary Phylloquinone and Menaquinones and Risk of Stroke
title_short Intake of Dietary Phylloquinone and Menaquinones and Risk of Stroke
title_sort intake of dietary phylloquinone and menaquinones and risk of stroke
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886750/
https://www.ncbi.nlm.nih.gov/pubmed/24326161
http://dx.doi.org/10.1161/JAHA.113.000455
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