Cardiac‐specific Hexokinase 2 Overexpression Attenuates Hypertrophy by Increasing Pentose Phosphate Pathway Flux

BACKGROUND: The enzyme hexokinase‐2 (HK2) phosphorylates glucose, which is the initiating step in virtually all glucose utilization pathways. Cardiac hypertrophy is associated with a switch towards increased glucose metabolism and decreased fatty acid metabolism. Recent evidence suggests that the in...

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Detalles Bibliográficos
Autores principales: McCommis, Kyle S., Douglas, Diana L., Krenz, Maike, Baines, Christopher P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886755/
https://www.ncbi.nlm.nih.gov/pubmed/24190878
http://dx.doi.org/10.1161/JAHA.113.000355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886755/
https://www.ncbi.nlm.nih.gov/pubmed/24190878
http://dx.doi.org/10.1161/JAHA.113.000355

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