Colorectal Tumors from APC*I1307K Carriers Principally Harbor Somatic APC Mutations outside the A8 Tract

PURPOSE: APC*I1307K (c.3920T>A) is an inherited variant associated with colorectal tumour risk found almost exclusively in those of Ashkenazi Jewish ancestry. A single nucleotide substitution creates an oligo-adenine tract (A8) that appears to be inherently prone to further mis-pairing and slippa...

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Detalles Bibliográficos
Autores principales: Zauber, Peter, Bishop, Timothy, Taylor, Claire, Sabbath-Solitare, Marlene, Marotta, Stephen, Tomlinson, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886998/
https://www.ncbi.nlm.nih.gov/pubmed/24416237
http://dx.doi.org/10.1371/journal.pone.0084498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886998/
https://www.ncbi.nlm.nih.gov/pubmed/24416237
http://dx.doi.org/10.1371/journal.pone.0084498

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