The Combination of RAD001 and MK-2206 Exerts Synergistic Cytotoxic Effects against PTEN Mutant Gastric Cancer Cells: Involvement of MAPK-Dependent Autophagic, but Not Apoptotic Cell Death Pathway

In the current study, we showed that the combination of mammalian target of rapamycin (mTOR) inhibitor RAD001 (everolimus) and Akt inhibitor MK-2206 exerted synergistic cytotoxic effects against low-phosphatase and tensin homolog (PTEN) gastric cancer cells (HGC-27 and SNU-601 lines). In HGC-27 cell...

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Detalles Bibliográficos
Autores principales: Ji, Dongmei, Zhang, Zhe, Cheng, Lei, Chang, Jinjia, Wang, Shanshan, Zheng, Biqiang, Zheng, Rongliang, Sun, Zuojun, Wang, Chenchen, Zhang, Zhiqing, Liu, Rujiao, Zhang, Xiaowei, Liu, Xin, Wang, Xiaofeng, Li, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887024/
https://www.ncbi.nlm.nih.gov/pubmed/24416349
http://dx.doi.org/10.1371/journal.pone.0085116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887024/
https://www.ncbi.nlm.nih.gov/pubmed/24416349
http://dx.doi.org/10.1371/journal.pone.0085116

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