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In Vivo Functions of CPSF6 for HIV-1 as Revealed by HIV-1 Capsid Evolution in HLA-B27-Positive Subjects

The host protein CPSF6 possesses a domain that can interact with the HIV-1 capsid (CA) protein. CPSF6 has been implicated in regulating HIV-1 nuclear entry. However, its functional significance for HIV-1 replication has yet to be firmly established. Here we provide evidence for two divergent functio...

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Detalles Bibliográficos
Autores principales: Henning, Matthew S., Dubose, Brittany N., Burse, Mallori J., Aiken, Christopher, Yamashita, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887095/
https://www.ncbi.nlm.nih.gov/pubmed/24415937
http://dx.doi.org/10.1371/journal.ppat.1003868