Prion Infection Impairs Cholesterol Metabolism in Neuronal Cells

Conversion of prion protein (PrP(C)) into a pathological isoform (PrP(Sc)) during prion infection occurs in lipid rafts and is dependent on cholesterol. Here, we show that prion infection increases the abundance of cholesterol transporter, ATP-binding cassette transporter type A1 (ATP-binding casset...

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Detalles Bibliográficos
Autores principales: Cui, Huanhuan L., Guo, Belinda, Scicluna, Benjamin, Coleman, Bradley M., Lawson, Victoria A., Ellett, Laura, Meikle, Peter J., Bukrinsky, Michael, Mukhamedova, Nigora, Sviridov, Dmitri, Hill, Andrew F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Lipids
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887205/
https://www.ncbi.nlm.nih.gov/pubmed/24280226
http://dx.doi.org/10.1074/jbc.M113.535807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887205/
https://www.ncbi.nlm.nih.gov/pubmed/24280226
http://dx.doi.org/10.1074/jbc.M113.535807

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