Structural Interactions between Inhibitor and Substrate Docking Sites Give Insight into Mechanisms of Human PS1 Complexes

Presenilin-mediated endoproteolysis of transmembrane proteins plays a key role in physiological signaling and in the pathogenesis of Alzheimer disease and some cancers. Numerous inhibitors have been found via library screens, but their structural mechanisms remain unknown. We used several biophysica...

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Detalles Bibliográficos
Autores principales: Li, Yi, Lu, Stephen Hsueh-Jeng, Tsai, Ching-Ju, Bohm, Christopher, Qamar, Seema, Dodd, Roger B., Meadows, William, Jeon, Amy, McLeod, Adam, Chen, Fusheng, Arimon, Muriel, Berezovska, Oksana, Hyman, Bradley T., Tomita, Taisuke, Iwatsubo, Takeshi, Johnson, Christopher M., Farrer, Lindsay A., Schmitt-Ulms, Gerold, Fraser, Paul E., St George-Hyslop, Peter H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887256/
https://www.ncbi.nlm.nih.gov/pubmed/24210759
http://dx.doi.org/10.1016/j.str.2013.09.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887256/
https://www.ncbi.nlm.nih.gov/pubmed/24210759
http://dx.doi.org/10.1016/j.str.2013.09.018

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