Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation

BACKGROUND: Heat shock protein 90 (HSP90) has a key role in the maintenance of the cellular proteostasis. However, HSP90 is also involved in stabilisation of oncogenic client proteins and facilitates oncogene addiction and cancer cell survival. The development of HSP90 inhibitors for cancer treatmen...

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Detalles Bibliográficos
Autores principales: Zhang, Y, Dayalan Naidu, S, Samarasinghe, K, Van Hecke, G C, Pheely, A, Boronina, T N, Cole, R N, Benjamin, I J, Cole, P A, Ahn, Y-H, Dinkova-Kostova, A T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887302/
https://www.ncbi.nlm.nih.gov/pubmed/24322890
http://dx.doi.org/10.1038/bjc.2013.710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887302/
https://www.ncbi.nlm.nih.gov/pubmed/24322890
http://dx.doi.org/10.1038/bjc.2013.710

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