Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex

LMO2 was discovered via chromosomal translocations in T-cell leukaemia and shown normally to be essential for haematopoiesis. LMO2 is made up of two LIM only domains (thus it is a LIM-only protein) and forms a bridge in a multi-protein complex. We have studied the mechanism of formation of this comp...

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Detalles Bibliográficos
Autores principales: Sewell, H., Tanaka, T., Omari, K. El, Mancini, E. J., Cruz, A., Fernandez-Fuentes, N., Chambers, J., Rabbitts, T. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887373/
https://www.ncbi.nlm.nih.gov/pubmed/24407558
http://dx.doi.org/10.1038/srep03643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887373/
https://www.ncbi.nlm.nih.gov/pubmed/24407558
http://dx.doi.org/10.1038/srep03643

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