Cargando…

The Circadian Clock in Murine Chondrocytes Regulates Genes Controlling Key Aspects of Cartilage Homeostasis

ObjectiveTo characterize the circadian clock in murine cartilage tissue and identify tissue-specific clock target genes, and to investigate whether the circadian clock changes during aging or during cartilage degeneration using an experimental mouse model of osteoarthritis (OA). MethodsCartilage exp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gossan, Nicole, Zeef, Leo, Hensman, James, Hughes, Alun, Bateman, John F, Rowley, Lynn, Little, Christopher B, Piggins, Hugh D, Rattray, Magnus, Boot-Handford, Raymond P, Meng, Qing-Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wiley Periodicals 2013
Materias:	Chondrocyte Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888512/ https://www.ncbi.nlm.nih.gov/pubmed/23896777 http://dx.doi.org/10.1002/art.38035

Ejemplares similares

Sphingosine 1-Phosphate Counteracts the Effects of Interleukin-1β in Human Chondrocytes
por: Stradner, Martin H, et al.
Publicado: (2013)

A Computer Simulation Approach to Assessing Therapeutic Intervention Points for the Prevention of Cytokine-Induced Cartilage Breakdown
por: Proctor, CJ, et al.
Publicado: (2014)

Fibroblast Growth Factor 2 Drives Changes in Gene Expression Following Injury to Murine Cartilage In Vitro and In Vivo
por: Chong, Ka-Wing, et al.
Publicado: (2013)

Ageing and osteoarthritis: a circadian rhythm connection
por: Gossan, Nicole, et al.
Publicado: (2014)

Gremlin-2 is a BMP antagonist that is regulated by the circadian clock
por: Yeung, Ching-Yan Chloé, et al.
Publicado: (2014)

Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NFкB-dependent pathway
por: Guo, B., et al.
Publicado: (2015)

Identifying spatial and temporal organization in the circadian clock (Commentary on Pauls et al.)
por: Piggins, Hugh D
Publicado: (2014)

The Kidney Clock Contributes to Timekeeping by the Master Circadian Clock
por: Myung, Jihwan, et al.
Publicado: (2019)

Cellular mechano-environment regulates the mammary circadian clock
por: Yang, Nan, et al.
Publicado: (2017)

Constant light enhances synchrony among circadian clock cells and promotes behavioral rhythms in VPAC(2)-signaling deficient mice
por: Hughes, Alun T.L., et al.
Publicado: (2015)

Ticking and talking in the brainstem satiety centre: Circadian timekeeping and interactions in the diet-sensitive clock of the dorsal vagal complex
por: Chrobok, Lukasz, et al.
Publicado: (2022)

Circadian time series proteomics reveals daily dynamics in cartilage physiology
por: Dudek, M., et al.
Publicado: (2021)

The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration
por: Dudek, Michal, et al.
Publicado: (2017)

Neuropeptide Signaling Differentially Affects Phase Maintenance and Rhythm Generation in SCN and Extra-SCN Circadian Oscillators
por: Hughes, Alun T. L., et al.
Publicado: (2011)

Circadian Disruptions in the Myshkin Mouse Model of Mania Are Independent of Deficits in Suprachiasmatic Molecular Clock Function
por: Timothy, Joseph W.S., et al.
Publicado: (2018)

Circadian clocks, feeding time, and metabolic homeostasis
por: Paschos, Georgios K.
Publicado: (2015)

The circadian clock and metabolic homeostasis: entangled networks
por: de Assis, Leonardo Vinícius Monteiro, et al.
Publicado: (2021)

Drivers of phenotypic variation in cartilage: Circadian clock genes
por: Song, Xiaopeng, et al.
Publicado: (2021)

Mesencephalic astrocyte-derived neurotropic factor is an important factor in chondrocyte ER homeostasis
por: Bell, P. A., et al.
Publicado: (2018)

A riot of rhythms: neuronal and glial circadian oscillators in the mediobasal hypothalamus
por: Guilding, Clare, et al.
Publicado: (2009)

Abnormal Chondrocyte Apoptosis in the Cartilage Growth Plate is Influenced by Genetic Background and Deletion of CHOP in a Targeted Mouse Model of Pseudoachondroplasia
por: Piróg, Katarzyna A., et al.
Publicado: (2014)

BMAL1 and CLOCK, Two Essential Components of the Circadian Clock, Are Involved in Glucose Homeostasis
por: Rudic, R. Daniel, et al.
Publicado: (2004)

Delayed Cryptochrome Degradation Asymmetrically Alters the Daily Rhythm in Suprachiasmatic Clock Neuron Excitability
por: Wegner, Sven, et al.
Publicado: (2017)

Circadian clocks: from stem cells to tissue homeostasis and regeneration
por: Dierickx, Pieterjan, et al.
Publicado: (2017)

Circadian Clock and OxInflammation: Functional Crosstalk in Cutaneous Homeostasis
por: Frigato, Elena, et al.
Publicado: (2020)

Circadian Clocks, Redox Homeostasis, and Exercise: Time to Connect the Dots?
por: McClean, Conor, et al.
Publicado: (2022)

Visualizing and Quantifying Intracellular Behavior and Abundance of the Core Circadian Clock Protein PERIOD2
por: Smyllie, Nicola J., et al.
Publicado: (2016)

Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis
por: Thomas, Rhian S, et al.
Publicado: (2011)

β-catenin signalling inhibits cartilage endplate chondrocyte homeostasis in vitro
por: Ding, Lei, et al.
Publicado: (2019)

Parathyroid hormone resets the cartilage circadian clock of the organ-cultured murine femur
por: Okubo, Naoki, et al.
Publicado: (2015)

Timed exercise stabilizes behavioral rhythms but not molecular programs in the brain’s suprachiasmatic clock
por: Hitrec, Timna, et al.
Publicado: (2023)

When Clocks Go Bad: Neurobehavioural Consequences of Disrupted Circadian Timing
por: Barnard, Alun R., et al.
Publicado: (2008)

Reciprocal Relationship Between Calcium Signaling and Circadian Clocks: Implications for Calcium Homeostasis, Clock Function, and Therapeutics
por: Cavieres-Lepe, Javier, et al.
Publicado: (2021)

Daily variation in the electrophysiological activity of mouse medial habenula neurones
por: Sakhi, Kanwal, et al.
Publicado: (2014)

Sleep homeostasis and the circadian clock: Do the circadian pacemaker and the sleep homeostat influence each other’s functioning?()
por: Deboer, Tom
Publicado: (2018)

Editorial: The circadian circus – how our clocks keep us ticking
por: Hughes, Alun Thomas Lloyd, et al.
Publicado: (2022)

Circadian Influences on the Habenula and Their Potential Contribution to Neuropsychiatric Disorders
por: Young, Callum J., et al.
Publicado: (2022)

Importance of mechanical cues in regulating musculoskeletal circadian clock rhythmicity: Implications for articular cartilage
por: Dintwa, Lekau, et al.
Publicado: (2023)

Development of human cartilage circadian rhythm in a stem cell-chondrogenesis model
por: Naven, Mark A, et al.
Publicado: (2022)

Circadian Clock and Photoperiodic Response in Arabidopsis: From Seasonal Flowering to Redox Homeostasis
por: Shim, Jae Sung, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_9qncngmh5kcv2bge9ctjkdplf3