Dynamics of yeast histone H2A and H2B phosphorylation in response to a double-strand break

In budding yeast, a single double-strand break (DSB) triggers extensive ATM (Tel1) and ATR (Mec1)-dependent phosphorylation of histone H2A (γ-H2AX) around the DSB. We describe Mec1- and Tel1-dependent phosphorylation of γ-H2B at H2B-T129. γ-H2B formation is impaired by γ-H2AX and its binding partner...

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Detalles Bibliográficos
Autores principales: Lee, Cheng-Sheng, Lee, Kihoon, Legube, Gaelle, Haber, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889172/
https://www.ncbi.nlm.nih.gov/pubmed/24336221
http://dx.doi.org/10.1038/nsmb.2737

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889172/
https://www.ncbi.nlm.nih.gov/pubmed/24336221
http://dx.doi.org/10.1038/nsmb.2737

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