Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain

Manipulation of gene expression in the brain is fundamental for understanding the function of proteins involved in neuronal processes. In this article, we show a method for using small interfering RNA (siRNA) in lipid nanoparticles (LNPs) to efficiently silence neuronal gene expression in cell cultu...

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Detalles Bibliográficos
Autores principales: Rungta, Ravi L, Choi, Hyun B, Lin, Paulo JC, Ko, Rebecca WY, Ashby, Donovan, Nair, Jay, Manoharan, Muthiah, Cullis, Pieter R, MacVicar, Brian A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889191/
https://www.ncbi.nlm.nih.gov/pubmed/24301867
http://dx.doi.org/10.1038/mtna.2013.65

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889191/
https://www.ncbi.nlm.nih.gov/pubmed/24301867
http://dx.doi.org/10.1038/mtna.2013.65

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