USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation

Physiological adaptation to proteotoxic stress in the endoplasmic reticulum (ER) requires retrotranslocation of misfolded proteins into the cytoplasm for ubiquitination and elimination by ER-associated degradation (ERAD). A surprising paradox emerging from recent studies is that ubiquitin ligases (E...

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Detalles Bibliográficos
Autores principales: Liu, Yanfen, Soetandyo, Nia, Lee, Jin-gu, Liu, Liping, Xu, Yue, Clemons, William M, Ye, Yihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889402/
https://www.ncbi.nlm.nih.gov/pubmed/24424410
http://dx.doi.org/10.7554/eLife.01369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889402/
https://www.ncbi.nlm.nih.gov/pubmed/24424410
http://dx.doi.org/10.7554/eLife.01369

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