A Mechanistic Framework for In Vitro–In Vivo Extrapolation of Liver Membrane Transporters: Prediction of Drug–Drug Interaction Between Rosuvastatin and Cyclosporine

BACKGROUND AND OBJECTIVES: The interplay between liver metabolising enzymes and transporters is a complex process involving system-related parameters such as liver blood perfusion as well as drug attributes including protein and lipid binding, ionisation, relative magnitude of passive and active per...

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Detalles Bibliográficos
Autores principales: Jamei, M., Bajot, F., Neuhoff, S., Barter, Z., Yang, J., Rostami-Hodjegan, A., Rowland-Yeo, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2013
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889821/
https://www.ncbi.nlm.nih.gov/pubmed/23881596
http://dx.doi.org/10.1007/s40262-013-0097-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889821/
https://www.ncbi.nlm.nih.gov/pubmed/23881596
http://dx.doi.org/10.1007/s40262-013-0097-y

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