Contextual inhibition of fatty acid synthesis by metformin involves glucose-derived acetyl-CoA and cholesterol in pancreatic tumor cells

Metformin, a generic glucose lowering drug, inhibits cancer growth expressly in models that employ high fat/cholesterol intake and/or low glucose availability. Here we use a targeted tracer fate association study (TTFAS) to investigate how cholesterol and metformin administration regulates glucose-d...

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Detalles Bibliográficos
Autores principales: Cantoria, Mary Jo, Boros, László G., Meuillet, Emmanuelle J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890070/
https://www.ncbi.nlm.nih.gov/pubmed/24482631
http://dx.doi.org/10.1007/s11306-013-0555-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890070/
https://www.ncbi.nlm.nih.gov/pubmed/24482631
http://dx.doi.org/10.1007/s11306-013-0555-4

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