Furin Is the Major Proprotein Convertase Required for KISS1-to-Kisspeptin Processing

KISS1 is a broadly functional secreted proprotein that is then processed into small peptides, termed kisspeptins (KP). Since sequence analysis showed cleavage at KR or RR dibasic sites of the nascent protein, it was hypothesized that enzyme(s) belonging to the proprotein convertase family of proteas...

Descripción completa

Detalles Bibliográficos
Autores principales: Harihar, Sitaram, Pounds, Keke M., Iwakuma, Tomoo, Seidah, Nabil G., Welch, Danny R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890299/
https://www.ncbi.nlm.nih.gov/pubmed/24454770
http://dx.doi.org/10.1371/journal.pone.0084958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890299/
https://www.ncbi.nlm.nih.gov/pubmed/24454770
http://dx.doi.org/10.1371/journal.pone.0084958

Ejemplares similares