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Furin Is the Major Proprotein Convertase Required for KISS1-to-Kisspeptin Processing
KISS1 is a broadly functional secreted proprotein that is then processed into small peptides, termed kisspeptins (KP). Since sequence analysis showed cleavage at KR or RR dibasic sites of the nascent protein, it was hypothesized that enzyme(s) belonging to the proprotein convertase family of proteas...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890299/ https://www.ncbi.nlm.nih.gov/pubmed/24454770 http://dx.doi.org/10.1371/journal.pone.0084958 |