Immunogenic, but Not Steady-State, Antigen Presentation Permits Regulatory T-Cells To Control CD8+ T-Cell Effector Differentiation by IL-2 Modulation

Absorption of IL-2 is one proposed mechanism of CD4+CD25+FoxP3+ regulatory T cell (Treg) suppression. Direct in vivo experimental evidence for this has recently been obtained. While modulation of IL-2 bioavailability controls CD8+ T-cell effector differentiation under strongly immunogenic conditions...

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Detalles Bibliográficos
Autores principales: McNally, Alice, McNally, Michael, Galea, Ryan, Thomas, Ranjeny, Steptoe, Raymond J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890313/
https://www.ncbi.nlm.nih.gov/pubmed/24454872
http://dx.doi.org/10.1371/journal.pone.0085455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890313/
https://www.ncbi.nlm.nih.gov/pubmed/24454872
http://dx.doi.org/10.1371/journal.pone.0085455

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