Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet Syndrome treatment

Dravet syndrome (DS) is a catastrophic pediatric epilepsy with severe intellectual disability, impaired social development and persistent drug-resistant seizures. One of its primary monogenic causes are mutations in Na(v)1.1 (SCN1A), a voltage-gated sodium channel. Here we characterise zebrafish Na(...

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Detalles Bibliográficos
Autores principales: Baraban, Scott C., Dinday, Matthew T., Hortopan, Gabriela A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891590/
https://www.ncbi.nlm.nih.gov/pubmed/24002024
http://dx.doi.org/10.1038/ncomms3410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891590/
https://www.ncbi.nlm.nih.gov/pubmed/24002024
http://dx.doi.org/10.1038/ncomms3410

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