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Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet Syndrome treatment
Dravet syndrome (DS) is a catastrophic pediatric epilepsy with severe intellectual disability, impaired social development and persistent drug-resistant seizures. One of its primary monogenic causes are mutations in Na(v)1.1 (SCN1A), a voltage-gated sodium channel. Here we characterise zebrafish Na(...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891590/ https://www.ncbi.nlm.nih.gov/pubmed/24002024 http://dx.doi.org/10.1038/ncomms3410 |