Intramolecular Telomeric G-Quadruplexes Dramatically Inhibit DNA Synthesis by Replicative and Translesion Polymerases, Revealing their Potential to Lead to Genetic Change

Recent research indicates that hundreds of thousands of G-rich sequences within the human genome have the potential to form secondary structures known as G-quadruplexes. Telomeric regions, consisting of long arrays of TTAGGG/AATCCC repeats, are among the most likely areas in which these structures m...

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Detalles Bibliográficos
Autores principales: Edwards, Deanna N., Machwe, Amrita, Wang, Zhigang, Orren, David K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891601/
https://www.ncbi.nlm.nih.gov/pubmed/24454683
http://dx.doi.org/10.1371/journal.pone.0080664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891601/
https://www.ncbi.nlm.nih.gov/pubmed/24454683
http://dx.doi.org/10.1371/journal.pone.0080664

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