ADAM17-mediated CD44 cleavage promotes orasphere formation or stemness and tumorigenesis in HNSCC

CD44, an extracellular matrix (ECM) receptor, has been described as a cancer stem cell marker in multiple cancers, including head and neck squamous cell carcinoma (HNSCC). HNSCC orasphere formation or stemness was characterized by cleavage of CD44, and thus we hypothesized that this proteolytic proc...

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Detalles Bibliográficos
Autores principales: Kamarajan, Pachiyappan, Shin, Jae M, Qian, Xu, Matte, Bibiana, Zhu, Joey Yizhou, Kapila, Yvonne L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892384/
https://www.ncbi.nlm.nih.gov/pubmed/24403253
http://dx.doi.org/10.1002/cam4.147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892384/
https://www.ncbi.nlm.nih.gov/pubmed/24403253
http://dx.doi.org/10.1002/cam4.147

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