BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I

The activation of the transcription factor hypoxia-inducible factor-1 (HIF-1) plays an essential role in tumor development, tumor progression, and resistance to chemo- and radiotherapy. In order to identify compounds targeting the HIF pathway, a small molecule library was screened using a luciferase...

Descripción completa

Detalles Bibliográficos
Autores principales: Ellinghaus, Peter, Heisler, Iring, Unterschemmann, Kerstin, Haerter, Michael, Beck, Hartmut, Greschat, Susanne, Ehrmann, Alexander, Summer, Holger, Flamme, Ingo, Oehme, Felix, Thierauch, Karlheinz, Michels, Martin, Hess-Stumpp, Holger, Ziegelbauer, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Science Inc 2013
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892793/
https://www.ncbi.nlm.nih.gov/pubmed/24403227
http://dx.doi.org/10.1002/cam4.112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892793/
https://www.ncbi.nlm.nih.gov/pubmed/24403227
http://dx.doi.org/10.1002/cam4.112

Ejemplares similares