Oxyphenisatin acetate (NSC 59687) triggers a cell starvation response leading to autophagy, mitochondrial dysfunction, and autocrine TNFα-mediated apoptosis

Oxyphenisatin (3,3-bis(4-hydroxyphenyl)-1H-indol-2-one) and several structurally related molecules have been shown to have in vitro and in vivo antiproliferative activity. This study aims to confirm and extend mechanistic studies by focusing on oxyphenisatin acetate (OXY, NSC 59687), the pro-drug of...

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Detalles Bibliográficos
Autores principales: Morrison, Bethanie L, Mullendore, Michael E, Stockwin, Luke H, Borgel, Suzanne, Hollingshead, Melinda G, Newton, Dianne L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Science Inc 2013
Materias:
Clinical Cancer Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892800/
https://www.ncbi.nlm.nih.gov/pubmed/24403234
http://dx.doi.org/10.1002/cam4.107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892800/
https://www.ncbi.nlm.nih.gov/pubmed/24403234
http://dx.doi.org/10.1002/cam4.107

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