Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation

We have assessed the role of B lymphocyte stimulator (BLyS) and its receptors in the germinal center (GC) reaction and affinity maturation. Despite ample BLyS retention on B cells in follicular (FO) regions, the GC microenvironment lacks substantial BLyS. This reflects IL-21–mediated down-regulation...

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Detalles Bibliográficos
Autores principales: Goenka, Radhika, Matthews, Andrew H., Zhang, Bochao, O’Neill, Patrick J., Scholz, Jean L., Migone, Thi-Sau, Leonard, Warren J., Stohl, William, Hershberg, Uri, Cancro, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892970/
https://www.ncbi.nlm.nih.gov/pubmed/24367004
http://dx.doi.org/10.1084/jem.20130505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892970/
https://www.ncbi.nlm.nih.gov/pubmed/24367004
http://dx.doi.org/10.1084/jem.20130505

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