CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets

Immune tolerance and activation depend on precise control over the number and function of immunosuppressive Foxp3(+) regulatory T (T reg) cells, and the importance of IL-2 in maintaining tolerance and preventing autoimmunity is clear. However, the homeostatic requirement for IL-2 among specific popu...

Descripción completa

Detalles Bibliográficos
Autores principales: Smigiel, Kate S., Richards, Elizabeth, Srivastava, Shivani, Thomas, Kerri R., Dudda, Jan C., Klonowski, Kimberly D., Campbell, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892972/
https://www.ncbi.nlm.nih.gov/pubmed/24378538
http://dx.doi.org/10.1084/jem.20131142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892972/
https://www.ncbi.nlm.nih.gov/pubmed/24378538
http://dx.doi.org/10.1084/jem.20131142

Ejemplares similares