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CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets

Immune tolerance and activation depend on precise control over the number and function of immunosuppressive Foxp3(+) regulatory T (T reg) cells, and the importance of IL-2 in maintaining tolerance and preventing autoimmunity is clear. However, the homeostatic requirement for IL-2 among specific popu...

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Detalles Bibliográficos
Autores principales:	Smigiel, Kate S., Richards, Elizabeth, Srivastava, Shivani, Thomas, Kerri R., Dudda, Jan C., Klonowski, Kimberly D., Campbell, Daniel J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892972/ https://www.ncbi.nlm.nih.gov/pubmed/24378538 http://dx.doi.org/10.1084/jem.20131142

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